Last updated on 23 September, 2025

Record statistics by species and TCR chain

General statistics. Note that general statistics are computed using the ‘slim’ database version. Slim version, for example, lists the same TCR sequence found in several donors/studies only once and selects representative V/J for a given CDR3aa clonotype and the best score across all redundant records.

Species Chain Records Paired records Unique epitopes Studies
HomoSapiens TRA 43964 36899 1505 223
HomoSapiens TRB 87610 66829 1694 278
MacacaMulatta TRB 1290 0 3 2
MusMusculus TRA 1742 1682 57 37
MusMusculus TRB 2878 1687 79 41

Record statistics by year

Number of unique TCR sequences, epitopes, MHC alleles and studies by publication year, cumulative plots.

Summary by antigen and antigen origin

Representative data for Homo Sapiens

Parent species Records Unique epitopes Studies
CMV 51311 153 52
HomoSapiens 38501 567 115
InfluenzaA 12258 38 31
EBV 11361 48 39
SARS-CoV-2 9045 671 18
HIV-1 3311 69 35
HCV 1913 22 12
M.tuberculosis 893 13 4
YFV 686 1 5
DENV 399 3 1
InfluenzaB 378 3 1
PlasmodiumFalciparum 282 6 1
TriticumAestivum 237 19 12
HTLV-1 220 8 8
SARS-CoV 143 1 1
Wheat 86 2 3
RotavirusA 84 3 1
CoxsackievirusB 65 2 1
synthetic 64 30 5
VZV 61 1 1
HCoV-HKU1 48 1 1
HIV 40 18 1
E.Coli 39 3 4
HSV-2 34 1 1
HPV 28 1 1
KlebsiellaOxytoca 22 2 1
AdV 15 2 1
MCPyV 12 2 1
CryptomeriaJaponica 8 1 1
AspergillusOryzae 6 3 1
StreptomycesKanamyceticus 6 1 1
FusariumOxysporum 4 2 1
HPV-16 4 2 1
CryptococcusNeoforman 2 1 1
HHV 2 1 1
PseudomonasAeruginosa 2 1 1
PseudomonasFluorescens 2 1 1
SaccharomycesCerevisiae 2 1 1

COVID-19 data

Summary of antigens and T-cell receptors related to COVID-19 pandemic. Number of records for SARS-CoV-2 epitopes grouped by viral protein and HLA plotted using alluvium plot. Epitopes with less than 30 records in total were not counted.

Summary of SARS-CoV-2 epitopes and corresponding TCR alpha and beta chain specificity records (cases with 10+ records)

Gene HLA Epitope Studies TRA TRB
Spike HLA-A.02 YLQPRTFLL 9 685 903
Nucleocapsid HLA-B.07 SPRWYFYYL 4 401 545
ORF1ab HLA-A.01 TTDPSFLGRY 3 394 438
Spike HLA-DPA.01/B.04 TFEYVSQPFLMDLE 2 102 445
Nucleocapsid HLA-A.03 KTFPPTEPK 2 128 167
Spike HLA-A.24 QYIKWPWYI 5 138 150
Spike HLA-A.01 LTDEMIAQY 2 125 129
Spike HLA-B.15 NQKLIANQF 1 75 73
Nucleocapsid HLA-A.02 RTATKQYNV 1 50 93
Spike HLA-A.02 RLQSLQTYV 5 53 88
Nucleocapsid HLA-B.40 MEVTPSGTWL 1 47 62
Spike HLA-A.24 NYNYLYRLF 3 56 52
ORF3 HLA-A.01 FTSDYYQLY 2 41 40
ORF3 HLA-A.02 LLYDANYFL 3 28 41
ORF3 HLA-A.02 ALSKGVHFV 3 24 40
ORF1ab HLA-A.02 ALWEIQQVV 2 27 36
ORF3 HLA-A.24 VYFLQSINF 2 29 29
ORF1ab HLA-A.01 PTDNYITTY 2 24 26
Matrix HLA-B.15 RVAGDSGFAAY 1 24 24
ORF1ab HLA-A.02 KLWAQCVQL 1 21 25
Nucleocapsid HLA-A.02 RTATKAYNV 1 19 23
Matrix HLA-B.07 WPVTLACFV 1 14 21
ORF1ab HLA-A.02 KSVNITFEL 1 16 19
NSP3 HLA-A.01 PTDNYITTY 1 13 19
Spike HLA-B.07 SIIAYTMSL 1 15 17
Spike HLA-DRA.01/B1.04 HWFVTQRNFYEPQII 1 16 16
ORF1ab HLA-A.02 VMVELVAEL 1 13 17
Matrix HLA-A.02 WLLWPVTLA 1 9 16
ORF14 HLA-A.02 LLLEWLAMA 1 10 13
Nucleocapsid HLA-A.02 LLLDRLNQL 2 4 18
ORF1ab HLA-A.02 TLMNVLTLV 1 9 13
Spike HLA-DRA.01/B1.04 NCTFEYVSQPFLMDL 1 6 16
ORF1ab HLA-A.24 TSQWLTNIF 1 10 11
ORF9b HLA-A.02 KVYPIILRL 1 9 12
Spike HLA-B.07 WPWYIWLGF 1 7 14
Spike HLA-DRA.01/B1.11 VGGNYNYLYRLFRKS 1 10 10
ORF1ab HLA-A.02 CLAVHECFV 1 9 10
ORF1ab HLA-A.02 FLAHIQWMV 1 8 11
ORF1ab HLA-A.02 FLLNKEMYL 1 9 10
ORF1ab HLA-A.02 RQLLFVVEV 1 9 10
NSP12 HLA-A.24 VYIGDPAQL 2 9 9
Nucleocapsid HLA-B.44 QELIRQGTDY 1 9 9
ORF1ab HLA-A.02 AIFYLITPV 1 7 11
ORF1ab HLA-A.02 FTVLCLTPV 1 7 11
Spike HLA-A.02 VFLVLLPLV 1 8 10
ORF1ab HLA-A.24 NYMPYFFTL 1 8 9
ORF3 HLA-A.02 YLYALVYFL 1 7 10
Spike HLA-A.02 RLITGRLQSL 1 9 8
ORF1ab HLA-A.01 NSSTCMMCY 1 6 10
ORF1ab HLA-A.02 KLQFTSLEI 1 8 8
ORF1ab HLA-A.02 YVDNSSLTI 1 7 9
ORF1ab HLA-A.02 KLKDCVMYA 1 7 8
ORF1ab HLA-A.02 YVWKSYVHV 1 6 9
ORF1ab HLA-B.07 MPASWVMRI 1 5 10
ORF1ab HLA-B.07 MPYFFTLLL 1 7 8
ORF7a HLA-B.07 SPIFRIVAA 1 4 11
Nucleocapsid HLA-A.01 NTNSSPDDQIGYY 1 7 7
Nucleocapsid HLA-B.07 RIRGGDGKM 1 6 8
ORF10 HLA-A.02 NVFAFPFTI 1 7 7
ORF1ab HLA-A.02 FLALCADSI 1 7 7
ORF1ab HLA-A.02 FLPRVFSAV 1 6 8
ORF1ab HLA-A.02 SVLYYQNNV 1 6 8
ORF1ab HLA-A.02 YMPYFFTLL 1 7 7
ORF1ab HLA-A.02 YTMADLVYA 1 5 9
RNP HLA-A.01 DTDFVNEFY 2 6 8
Spike HLA-A.02 IMLCCMTSC 1 6 8
Spike HLA-B.44 AEVQIDRLI 1 7 7
Spike HLA-DRA.01/B1.03 RISNCVADYSVLYNS 1 7 7
ORF1ab HLA-A.02 FLPGVYSVI 1 5 8
ORF1ab HLA-A.02 LLDDFVEII 1 6 7
Spike HLA-A.02 KQIYKTPPI 2 6 7
Spike HLA-DRA.01/B1.15 NLLLQYGSFCTQLNRAL 1 0 13
Matrix HLA-A.24 LWLLWPVTL 1 6 6
Nucleocapsid HLA-A.02 LLNKHIDAY 1 4 8
ORF1ab HLA-A.02 KLNEEIAII 1 5 7
ORF1ab HLA-A.02 KLSYGIATV 1 4 8
ORF1ab HLA-A.02 LMIERFVSL 1 5 7
ORF1ab HLA-A.02 RIMTWLDMV 1 4 8
ORF1ab HLA-A.02 SMMILSDDA 1 6 6
ORF1ab HLA-A.02 YLFDESGEF 1 5 7
ORF1ab HLA-B.07 SPYNSQNAV 1 4 8
Spike HLA-DRA.01/B1.03 NFSQILPDPSKPSKR 1 6 6
Matrix HLA-A.02 LACFVLAAV 1 4 7
ORF1ab HLA-A.01 YADVFHLYL 1 5 6
ORF1ab HLA-A.02 FLNRFTTTL 1 5 6
ORF1ab HLA-A.02 TLMNVITLV 1 5 6
ORF1ab HLA-A.02 TTIQTIVEV 1 5 6
ORF1ab HLA-A.02 YADVFHLYL 1 5 6
ORF1ab HLA-A.02 YLGGMSYYC 1 5 6
ORF1ab HLA-B.07 VPYFNMVYM 1 4 7
Spike HLA-A.02 FIAGLIAIV 2 4 7
ORF1ab HLA-A.01 FLTENLLLY 1 4 6
ORF1ab HLA-A.01 TSAMQTMLF 1 4 6
ORF1ab HLA-A.02 LMCQPILLL 1 4 6
ORF1ab HLA-A.02 MLDMYSVML 1 5 5
ORF1ab HLA-A.02 SMWALVISV 1 5 5
ORF1ab HLA-A.02 TLKNTVCTV 1 5 5
ORF1ab HLA-A.24 VMHANYIFW 1 5 5
ORF7a HLA-A.02 KLFIRQEEV 1 5 5
ORF7b HLA-A.02 LLFLVLIML 1 5 5
Spike HLA-A.02 FLHVTYVPA 1 5 5
Spike HLA-DQA1.01/B1.06 NNSYECDIPIGAGIC 1 5 5

Self-antigen data

Summary of T-cell receptors recognizing self-antigens, including antigens linked to utoimmune diseases and potential neoantigen targets for cancer immunotherapy. Number of records for self-antigens grouped by (mutated) human gene and corresponding HLAs are plotted using alluvium plot. Only self-antigens with at least 10 records are shown.

Summary of neoantigens and corresponding TCR alpha and beta chain specificity records (cases with 10+ records)

Gene HLA Epitope Studies TRA TRB
NY-ESO-1 HLA-A.02 SLLMWITQV 4 37 29698
MLANA HLA-A.02 ELAGIGILTV 16 370 1431
PGT HLA-A.02 LLAGIGTVPI 1 479 885
BST2 HLA-A.02 LLLGIGILV 1 384 233
KLK3 HLA-A.02 VISNDVCAQV 1 229 362
MART1 HLA-A.02 ALAGIGILTV 1 97 150
APOB HLA-DRA.01/B1.07 SLFFSAQPFEITAST 1 104 104
IGF2BP2 HLA-A.02 NLSALGIFST 1 0 112
MLANA HLA-A.02 ALGIGILTV 2 40 52
SF3B1 HLA-A.02 RLPGVLPRA 1 43 48
TKT HLA-A.02 AMFWSVPTV 1 0 83
G6PC2 HLA-A.01 LTSLTILQLY 1 34 36
ZNT8 HLA-B.08 YAKWKLCSA 1 28 41
PLA2G6 HLA-A.02 FLASKIGRLV 1 34 34
ZNT8 HLA-B.08 YAYAKWKL 1 31 32
ZNT8 HLA-A.02 LLSLFSLWL 1 24 38
SEC24A HLA-A.02 FLYNLLTRV 1 0 61
MLANA HLA-A.02 EAAGIGILTV 7 15 45
PMEL HLA-A.02 IMDQVPFSV 4 13 45
ZNT8 HLA-A.01 VTDAAHLLI 1 23 33
SLC30A8 HLA-A.02 VAANIVLTV 2 24 29
ZNT8 HLA-A.02 VVTGVLVYL 1 23 27
IAPP HLA-A.01 STNVGSNTY 1 16 27
INS HLA-DQA1.03/B1.02 GQVELGGGNAVEVCK 2 21 21
GAD65 HLA-A.02 VMNILLQYV 1 15 24
GFAP HLA-B.08 HLKRNIVV 1 16 23
G6PC2 HLA-B.08 NLIFKWIL 1 18 19
INS HLA-B.08 MALWMRLL 1 17 20
GAD2 HLA-B.08 MMIARFKM 1 15 21
PORCN HLA-A.02 LLHGFSFYL 1 0 36
MLANA HLA-A.02 ELAGIGLTV 1 22 13
IGRP HLA-A.02 FLWSVFWLI 1 12 22
PREINS HLA-A.02 ALWMRLLPL 1 15 18
PMEL HLA-A.02 KTWGQYWQV 1 16 16
PMEL HLA-A.02 YLEPGPVTV 2 1 31
ZNT8 HLA-A.02 IQATVMIIV 1 12 20
WT1 HLA-A.24 CYTWNQMNL 1 15 15
NY-ESO-1 HLA-DQA.01/B1.07 LLEFYLAMPFATP 1 13 16
ZNT8 HLA-A.02 KMYAFTLES 1 9 20
IGRP HLA-A.02 VLFGLGFAI 1 10 18
WT1 HLA-A.02 RMFPNAPYL 5 14 14
PREINS HLA-A.02 RLLPLLALL 1 12 15
CTAG1B HLA-DRA.01/B3.02 LKEFTVSGNILTIRL 1 12 13
G6PC2 HLA-B.08 YLKTNLFL 1 9 15
GAD2 HLA-A.01 VSATAGTTVY 1 14 10
IAPP HLA-B.08 ILKLQVFL 1 9 15
INS HLA-A.01 GSHLVEALY 1 10 14
INS HLA-A.02 RLLPLLALLAL 1 7 17
CLK3 HLA-A.02 RLWGTWVKA 1 11 11
ZDBF2 HLA-A.02 YILKYSVFL 1 0 21
IAPP HLA-A.02 KLQVFLIVL 1 6 14
INS HLA-A.24 LWMRLLPLL 1 8 12
SRPX HLA-A.02 TLWCSPIKV 2 10 10
AKAP13 HLA-A.02 KLMNIQQKL 1 0 19
NY-ESO-1 HLA-DRA.01/B1.04 PGVLLKEFTVSGNIL 1 9 10
ZNT8 HLA-A.02 ILSAHVATA 1 9 9
PTPRN HLA-A.02 LLPPLLEHL 1 8 9
IGRP HLA-A.02 LNIDLLWSV 1 8 8
IGRP HLA-A.02 NLFLFLFAV 1 5 11
MAGEA1 HLA-A.02 KVLEYVIKV 1 8 8
MLANA HLA-DRA.01/B3.02 EPVVNAPPAYEKLS 1 8 8
ZNT8 HLA-A.02 LAVDGVLSV 1 9 7
ADH HLA-A.02 RQFGPDWIVA 1 6 9
FNDC3B HLA-A.02 VVMSWAPPV 1 7 8
GFAP HLA-B.08 LRLRLDQL 1 6 9
INS HLA-B.08 LWMRLLPL 1 7 8
MLANA HLA-A.02 AAGIGILTV 4 5 10
ZNT8 HLA-A.02 LLSILCIWV 1 5 10
5T4 HLA-A.02 RLARLALVL 1 7 7
BCL2L1 HLA-A.02 YLNDHLEPWI 1 7 7
INS HLA-B.08 WMRLLPLL 1 6 8
SLC3A2 HLA-DRA.01/B1.07 DPPALASTNAEVT 1 7 7
TERT HLA-DRA.01/B3.02 GTAFVQMPAHGLFPW 1 7 7
TYR HLA-A.02 CLLWSFQTSA 1 7 7
GAD2 HLA-B.08 EAKQKGFVPF 1 5 8
GAD2 HLA-B.08 TLKKMREI 1 5 8
GCN1L1 HLA-A.02 SLLRSLENV 1 0 13
PTPRN HLA-A.02 VIVMLTPLV 1 5 8
PTPRN HLA-B.08 HARIKLKV 1 6 7
ZNT8 HLA-A.01 PTEKGANEY 1 6 7
AKAP9 HLA-A.02 RLSDFSEQL 1 0 12
EXOC8 HLA-A.02 IILVAVPHV 1 0 12
GAD2 HLA-B.08 SRKHKWKL 1 5 7
GANAB HLA-A.02 ALYGFVPVL 1 6 6
GFAP HLA-A.01 ALDIEIATY 1 6 6
PMEL HLA-A.02 ITDQVPFSV 3 3 9
INS HLA-A.02 LALWGPDPAA 1 4 7
PABPC1 HLA-A.02 MLGEQLFPL 1 0 11
PTPRN HLA-A.02 MVWESGCTV 1 3 8
GAD2 HLA-A.01 QQDKHYDLSY 1 4 6
GAD2 HLA-B.08 FQQDKHYDL 1 6 4
IAPP HLA-B.08 LNHLKATPI 1 4 6
INSDRIP HLA-A.02 MLYQHLLPL 1 4 6
NDC1 HLA-A.02 CLNEYHLFL 1 0 10
NY-ESO-1 HLA-B.07 APRGPHGGAASGL 2 5 5

Distribution VDJdb confidence scores

Legend: 0 - low confidence, 1 - medium confidence, 2 - high confidence, 3 - very high confidence.

Note that this scoring system is currently deprecated due to large amounts of deep multimer+ repertoire sequencing data and 10X scRNAseq with ImmuDEX dextramer multiplex that are almost impossible to validate independently. We suggest applying methods like TCRNET to infer high-confidence TCR motifs from VDJdb.


Spectratype

Representative data for Homo Sapiens. CDR3 length distribution (spectratype) is colored by cognate epitope. Second plot shows epitope length distribution for MHC class I and II colored by unique CDR3 (alpha or beta) records.

V(D)J usage and MHC alleles

Representative data for Homo Sapiens, Variable gene. Only Variable genes and MHC alleles with at least 10 records are shown.

Circos plot for correspondence between human TRBV genes and MHC class I alleles for links supported by more than 50 records in terms of the ratio of observed to expected records. Band width and color (from red:highest to light yellow:lowest) are scaled proportional to co-occurrence matrix value divided by row (TRBV) and column (HLA) sums.


Detailed summary for HLA

Representative data for Homo Sapiens MHC class I and II

First chain Second chain Records Unique epitopes Studies
HLA-A*02 B2M 81361 948 152
HLA-A*03 B2M 25903 17 13
HLA-A*11 B2M 4767 10 10
HLA-B*08 B2M 4282 67 23
HLA-A*01 B2M 3075 159 21
HLA-B*07 B2M 2620 123 29
HLA-DRA*01 HLA-DRB1*01 1259 15 12
HLA-A*24 B2M 1058 82 17
HLA-E*01 B2M 848 9 4
HLA-B*27 B2M 824 71 15
HLA-B*57 B2M 732 9 8
HLA-DPA*01 HLA-DPB*04 547 1 2
HLA-DRA*01 HLA-DRB1*04 428 13 9
HLA-DRA*01 HLA-DRB5*01 384 8 7
HLA-B*35 B2M 375 42 23
HLA-B*42 B2M 354 12 6
HLA-DQA1*05 HLA-DQB1*02 309 17 10
HLA-DRA1*01 HLA-DRB1*15 306 1 1
HLA-DRA*01 HLA-DRB1*07 298 10 7
HLA-B*44 B2M 293 9 7
HLA-DRA*01 HLA-DRB1*15 243 9 8
HLA-B*15 B2M 233 6 4
HLA-A*68 B2M 212 4 4
HLA-DRA*01 HLA-DRB1*11 192 5 6
HLA-A*08 B2M 117 1 1
HLA-B*40 B2M 113 3 2
HLA-B*18 B2M 82 9 3
HLA-DQA1*03 HLA-DQB1*02 62 9 3
HLA-DRA*01 HLA-DRB3*02 59 4 2
HLA-DQA1*01 HLA-DQB1*06 49 6 6
HLA-B*81 B2M 48 1 2
HLA-C*07 B2M 43 3 2
HLA-DRA*01 HLA-DRB1*03 42 5 3
HLA-DQA1*02 HLA-DQB1*02 32 6 2
HLA-DPA1*01 HLA-DPB1*04 30 8 1
HLA-DRA1*01 HLA-DRB1*11 30 1 1
HLA-B*51 B2M 29 1 1
HLA-DQA*01 HLA-DRB1*07 29 1 1
HLA-DQA1*03 HLA-DQB1*03 23 7 6
HLA-DQA1*01 HLA-DQB1*02 20 1 1
HLA-DQA1*02 HLA-DQB1*06 20 1 1
HLA-DPA1*02 HLA-DPB1*13 16 1 1
HLA-DQA1*05 HLA-DQB1*03 14 5 3
HLA-C*08 B2M 10 3 3
HLA-DQA1*01 HLA-DQB1*05 10 5 4
HLA-B*53 B2M 9 1 1
HLA-DRA*01 HLA-DRB3*03 9 3 3
DPA1*02 DPB1*05 8 1 1
HLA-B*38 B2M 7 3 2
HLA-A*29 B2M 6 3 1
HLA-DPA1*02 HLA-DPB1*01 6 3 1
HLA-DPA1*02 HLA-DPB1*14 6 3 1
HLA-C*01 B2M 4 1 1
HLA-C*03 B2M 4 2 2
HLA-DPA1*01 HLA-DPB1*02 4 2 2
HLA-A*30 B2M 3 1 1
HLA-DRB1*07 HLA-DRA*01 3 1 1
HLA-A*25 B2M 2 1 1
HLA-B*12 B2M 2 1 1
HLA-B*37 B2M 2 1 1
HLA-B*58 B2M 2 1 1
HLA-C*05 B2M 2 1 1
HLA-C*06 B2M 2 1 1
HLA-C*14 B2M 2 1 1
HLA-DPA1*01 HLA-DPB1*03 2 1 1
HLA-DRA*01 HLA-DRB1*09 2 1 1
HLA-DRA*01 HLA-DRB1*13 2 1 1
HLA-A*32 B2M 1 1 1
HLA-B*14 B2M 1 1 1
HLA-B*52 B2M 1 1 1
HLA-C*04 B2M 1 1 1